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Hybrid Hernia Repair Device

Multicenter clinical trial1

Five centers participated in this Zenapro trial.

The patient population

Patients had comorbidities such as smoking history, hypertension, insulin-dependent diabetes, and previous surgery.

Low levels of inflammation

Trichrome stains in an adhesiogenesis model show that Zenapro is associated with comparatively low levels of inflammatory response while it provides a scaffold for host cell infiltration. Results from a three-week, rat-model study.2



Zenapro vs. Omega-3 coated mesh

Zenapro vs. Hydrogel-coated mesh

Zenapro vs. Uncoated polypropylene mesh

Zenapro strength characteristics

Three-week data

Zenapro strength characteristics
  • Transverse Transverse
  • Longitudinal Longitudinal
  • <sup>‡</sup>Tensile strength requirement for bridging defect patch <br>type repair.<sup>3</sup> Tensile strength requirement for bridging defect patch
    type repair.3

What happens in the body with Zenapro?

Increasing incorporation

Six months after implantation, Zenapro shows organized tissue deposition that surrounds the mesh. The hydrogel-coated synthetic mesh, however, seems unchanged six months after implantation. Results from a six-month, rabbit-model study.2



Hydrogel-coated synthetic

Hydrogel-coated synthetic

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  1. Strong A, El-Hayek K, Phillips M, et al. First human use of hybrid synthetic/biologic mesh in ventral hernia repair: 1 year results of a multicenter trial.
    Paper presented at: 18th Annual Hernia Repair Meeting of Americas Hernia Society; March 8, 2017; Cancun, Mexico.
  2. Histology and benchtop testing conducted at Cook Biotech. Data on file.
  3. Klosterhalfen B, Junge K, Klinge U. The lightweight and large porous mesh concept for hernia repair. Expert Rev Med Devices. 2005;9(2):115-119.